The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2019
Filed:
Feb. 03, 2015
Applicant:
Ohio State Innovation Foundation, Columbus, OH (US);
Inventors:
Michael Caligiuri, Columbus, OH (US);
Robert Lee, Columbus, OH (US);
Guido Marcucci, Columbus, OH (US);
Assignee:
Ohio State Innovation Foundation, Columbus, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 5/06 (2006.01); A61K 38/05 (2006.01); A61K 9/127 (2006.01); C07F 5/04 (2006.01); A61K 47/54 (2017.01);
U.S. Cl.
CPC ...
C07K 5/06191 (2013.01); A61K 9/127 (2013.01); A61K 38/05 (2013.01); A61K 47/543 (2017.08); A61K 47/544 (2017.08); C07F 5/04 (2013.01);
Abstract
Provided herein are boronic acid esters of boronic acid therapeutic agents, such as bortezomib. The boronic acid esters can be used to prepare liposomal formulations of boronic acid therapeutic agents with improved properties, such as enhanced stability. This disclosure, in one aspect, relates to compositions and methods of making and using the compositions.