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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10167283 B1

PDFFull Text
Date of Patent:
Jan. 01, 2019

Filed:

Aug. 18, 2016

β-lactamase inhibitors and uses thereof

Applicants:

Xuanzhu Pharma Co., Ltd., Jinan, Shandong Province, CN;

Sihuan Pharmaceutical Holdings Group Ltd., Beijing, CN;

Inventor:

Frank Wu, Jinan, CN;

Assignees:

SUANZHU PHARMA CO., LTD., Jinan, Shandong Province, CN;

SIHUAN PHARMACEUTICAL HOLDINGS GROUP LTD., Beijing, CN;

Attorney:

Christensen O'Connor Johnson Kindness PLLC

Primary Examiner:

Kahsay Habte

Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 471/08 (2006.01); A61K 31/439 (2006.01); A61K 31/535 (2006.01); C07D 487/08 (2006.01); C07D 519/00 (2006.01); A61P 31/04 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/08 (2013.01); A61K 31/439 (2013.01); A61K 31/535 (2013.01); A61K 45/06 (2013.01); A61P 31/04 (2018.01); C07D 487/08 (2013.01); C07D 519/00 (2013.01); Y02A 50/471 (2018.01); Y02A 50/473 (2018.01); Y02A 50/475 (2018.01); Y02A 50/481 (2018.01);
Abstract

The present invention relates to a compound of Formula (I)-(IV) useful as β-lactamase inhibitor, a pharmaceutically acceptable salt, ester, solvate or stereoisomer thereof, wherein R, R, M and ring A have definitions as those in the specification. The present invention further relates to methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and uses of these compounds. For example, the compounds of the present invention can be used as β-lactamase inhibitors, for treatment and/or prophylaxis of diseases caused by bacterial infections, solving drug-resistance problems caused by β-lactamases, especially bacterial drug-resistant diseases caused by type B metallo-β-lactamases.

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