The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2019
Filed:
Oct. 27, 2016
Applicant:
Parion Sciences, Inc., Durham, NC (US);
Inventor:
Michael R. Johnson, Chapel Hill, NC (US);
Assignee:
Parion Sciences, Inc., Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/496 (2006.01); C07D 241/28 (2006.01); C07D 241/26 (2006.01); A61K 31/4965 (2006.01); A61K 31/497 (2006.01); A61K 31/706 (2006.01); A61K 45/06 (2006.01); C07D 241/32 (2006.01); C07D 405/12 (2006.01); C07H 15/26 (2006.01);
U.S. Cl.
CPC ...
C07D 241/28 (2013.01); A61K 31/497 (2013.01); A61K 31/4965 (2013.01); A61K 31/706 (2013.01); A61K 45/06 (2013.01); C07D 241/26 (2013.01); C07D 241/32 (2013.01); C07D 405/12 (2013.01); C07H 15/26 (2013.01);
Abstract
The present invention relates to compounds of Formula (I) and pharmaceutical compositions thereof. Compounds of Formula (I) are epithelial sodium channel (ENaC) blockers useful in the hydration of mucosal surfaces, enhancement of mucociliary clearance, or restoration of mucosal defense in a subject. The compounds and compositions can therefore be used to treat diseases which rely on the hydration of mucosal surfaces.