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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10167259 B1

PDFFull Text
Date of Patent:
Jan. 01, 2019

Filed:

Jun. 13, 2014

Allosteric inhibitors of proteasome and methods of use thereof

Applicant:

The Board of Regents of the University of Texas System, Austin, TX (US);

Inventors:

Pawel A. Osmulski, San Antonio, TX (US);

Maria E. Gaczynska, San Antonio, TX (US);

Assignee:

The Board of Regents of the University of Texas System, Austin, TX (US);

Attorney:

Parker Highlander PLLC

Primary Examiner:

Yong S Chong

Int. Cl.
CPC ...
C07D 211/60 (2006.01); A61K 45/06 (2006.01); A61K 31/69 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01); C07D 498/08 (2006.01);
U.S. Cl.
CPC ...
C07D 211/60 (2013.01); A61K 31/69 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 413/12 (2013.01); C07D 498/08 (2013.01);
Abstract

The present invention relates generally to novel allosteric regulators of proteasome activity, methods for preparation and use, and pharmaceutical compositions thereof. Specifically piperidine-2-carboxylic acid derivatives containing 1-oxo-aroyl group and a lipophilic ester side chain are disclosed as allosteric inhibitors of proteasome 2S activity, and as therapeutic agents for the treatment of proteasome-associated disorders in a subject.

Find Patent Forward Citations

Osmulski, Pawel. (2019). Allosteric inhibitors of proteasome and methods of use thereof (U.S. Patent No. 10167259). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10167259

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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