The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2019
Filed:
Jun. 13, 2014
Applicant:
The Board of Regents of the University of Texas System, Austin, TX (US);
Inventors:
Pawel A. Osmulski, San Antonio, TX (US);
Maria E. Gaczynska, San Antonio, TX (US);
Assignee:
The Board of Regents of the University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/60 (2006.01); A61K 45/06 (2006.01); A61K 31/69 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01); C07D 498/08 (2006.01);
U.S. Cl.
CPC ...
C07D 211/60 (2013.01); A61K 31/69 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 413/12 (2013.01); C07D 498/08 (2013.01);
Abstract
The present invention relates generally to novel allosteric regulators of proteasome activity, methods for preparation and use, and pharmaceutical compositions thereof. Specifically piperidine-2-carboxylic acid derivatives containing 1-oxo-aroyl group and a lipophilic ester side chain are disclosed as allosteric inhibitors of proteasome 2S activity, and as therapeutic agents for the treatment of proteasome-associated disorders in a subject.