The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 01, 2019

Filed:

May. 26, 2016
Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Elisa E. Konofagou, New York, NY (US);

James J. Choi, Englewood, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61M 37/00 (2006.01); A61B 17/225 (2006.01); A61B 8/08 (2006.01); A61B 5/00 (2006.01); A61B 5/055 (2006.01);
U.S. Cl.
CPC ...
A61M 37/0092 (2013.01); A61B 5/0071 (2013.01); A61B 5/055 (2013.01); A61B 8/0808 (2013.01); A61B 8/481 (2013.01); A61B 17/225 (2013.01); A61B 8/0816 (2013.01); A61M 2202/0007 (2013.01); A61M 2205/0244 (2013.01); A61M 2205/058 (2013.01); A61M 2210/0693 (2013.01); A61M 2210/12 (2013.01); A61M 2250/00 (2013.01);
Abstract

Systems and methods for opening a tissue to a target value using microbubbles are disclosed herein. In an embodiment of a method for opening a tissue to a target value using microbubbles, a region of the tissue is targeted for opening, an acoustic parameter corresponding to the target value is determined, and an ultrasound beam is applied to the target region at the acoustic parameter such that the tissue at the target region is opened to the target value with the microbubbles. The acoustic parameter can be selected to control an acoustic cavitation event and, in some embodiments, controlling an acoustic cavitation event can include controlling a location, number and/or magnitude of acoustic cavitation events.


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