The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 01, 2019

Filed:

Jun. 04, 2014
Applicants:

Virginia Commonwealth University, Richmond, VA (US);

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Paul B. Fisher, Richmond, VA (US);

Swadesh K. Das, Richmond, VA (US);

Mitchell E. Menezes, Richmond, VA (US);

Devanand Sarkar, Richmond, VA (US);

Martin G. Pomper, Baltimore, MD (US);

Assignees:

Virginia Commonwealth University, Richmond, VA (US);

The Johns Hopkins University, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61K 9/14 (2006.01); C12N 15/63 (2006.01); C07H 21/04 (2006.01); A61K 48/00 (2006.01); A61K 41/00 (2006.01); A61K 49/00 (2006.01); A61K 51/04 (2006.01); C12Q 1/6897 (2018.01); A61K 9/00 (2006.01); C12N 15/86 (2006.01); A61K 38/20 (2006.01); C12N 7/00 (2006.01); C12N 15/87 (2006.01); A61K 51/12 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0058 (2013.01); A61K 9/0019 (2013.01); A61K 38/20 (2013.01); A61K 41/0028 (2013.01); A61K 41/0033 (2013.01); A61K 49/0013 (2013.01); A61K 49/0045 (2013.01); A61K 49/0054 (2013.01); A61K 51/00 (2013.01); A61K 51/0491 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12N 15/87 (2013.01); C12Q 1/6897 (2013.01); A61K 51/12 (2013.01); C07H 21/04 (2013.01); C12N 2710/10043 (2013.01); C12N 2710/10343 (2013.01); C12N 2710/16143 (2013.01); C12N 2710/16171 (2013.01); C12N 2830/008 (2013.01);
Abstract

The presently disclosed subject matter generally relates to genetic constructs and methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. In particular, the presently disclosed subject matter relates to tripartite cancer theranostic nucleic acid constructs that permit simultaneous cancer specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.


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