The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 01, 2019

Filed:

Dec. 20, 2016
Applicant:

The Board of Trustees of the University of Illinois, Urbana, IL (US);

Inventors:

Paul J. Hergenrother, Champaign, IL (US);

Karson S. Putt, Lafayette, IN (US);

Quinn P. Peterson, Urbana, IL (US);

Valerie Fako, Naperville, IL (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/445 (2006.01); C07D 211/62 (2006.01); C07D 295/13 (2006.01); C07D 295/15 (2006.01); C07D 295/03 (2006.01); C07D 401/12 (2006.01); A61K 31/45 (2006.01);
U.S. Cl.
CPC ...
A61K 31/495 (2013.01); A61K 31/445 (2013.01); A61K 31/45 (2013.01); A61K 31/496 (2013.01); C07D 211/62 (2013.01); C07D 295/03 (2013.01); C07D 295/13 (2013.01); C07D 295/15 (2013.01); C07D 401/12 (2013.01);
Abstract

Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.


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