The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2019
Filed:
May. 02, 2017
Tianjin Hemay Bio-tech Co., Ltd., Tianjin, CN;
Hesheng Zhang, Tianjin, CN;
Tianjin Hemay Bio-Tech Co., Ltd., Tianjin, CN;
Abstract
This invention is directed to derivatives of piperidine-2,6-dione, or their organic or inorganic salts thereof, a methods of synthesis of these derivatives, and their application as active pharmaceutical ingridient as inhibitors of TNFα releasing in cells, the derivative of piperidine-2,6-dione being of the general formula (I): wherein n represents 1, 2, 3, 4, 5 or 6; Rrepresents from one to four of the same or different substituents selected from F, Cl, Br, Calkyl, OH, OCalkyl, NO, NHC(O)Calkyl, NH, NH(Calkyl), N(Calkyl); Rrepresents OR, NRR, N(R)COR, OCR; Rand Rrepresent independently and at each occurrence H or Calkyl; Rrepresents CHRNRR, CHRNRC(O)CHRNRR, a heterocycle W or CHRNRC(O)W; R, R, Rrepresent independently and at each occurrence H, or Calkyl; Rand Rrepresent independently and at each occurrence H, Calkyl, or Rand Rtaken together represent 1,3-propylene, 1,4-butylene, 1,5-pentylene , or 1,6-hexylene; W represents four-membered, five-membered, six-membered, seven-membered, or eight-membered saturated or unsaturated heterocycle.