The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2018
Filed:
Oct. 29, 2013
Applicant:
Lonza Ltd, Visp, CH;
Inventors:
Assignee:
Lonza Ltd, Visp, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/62 (2006.01); C12N 15/81 (2006.01); C12N 1/19 (2006.01); C12P 21/00 (2006.01); C12P 21/02 (2006.01); C07K 14/435 (2006.01); C07K 14/765 (2006.01); C12N 9/64 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
C12P 21/02 (2013.01); C07K 14/43595 (2013.01); C07K 14/765 (2013.01); C07K 16/00 (2013.01); C12N 9/6478 (2013.01); C12N 15/815 (2013.01); C07K 2317/56 (2013.01);
Abstract
An isolated nucleic acid encoding a leader, which has a specific sequence, an isolated leader peptide encoded by such nucleic acid, an expression cassette comprising such nucleic acid encoding a leader operably linked to a nucleic acid sequence encoding a POI, a recombinant yeast host cell or a vector comprising such expression cassette, a method of producing a POI in such yeast host cell, and further the use of the specific nucleic acid for the secretion of a POI from a host cell and/or to increase the secretion of a POI from a host cell.