The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2018
Filed:
Apr. 10, 2015
Medimmune, Llc, Gaithersburg, MD (US);
John Li, Gaithersburg, MD (US);
Nazzareno Dimasi, Gaithersburg, MD (US);
Steven Coats, Gaithersburg, MD (US);
Melissa Damschroder, Gaithersburg, MD (US);
Changshou Gao, Gaithersburg, MD (US);
Godfrey Rainey, Gaithersburg, MD (US);
Cuihua Gao, Gaithersburg, MD (US);
Dorin Toader, Gaithersburg, MD (US);
Lakshmaiah Gingipalli, Waltham, MA (US);
Fengjiang Wang, Gaithersburg, MD (US);
Ryan Fleming, Gaithersburg, MD (US);
Binyam Bezabeh, Gaithersburg, MD (US);
Andy Qingan Yuan, Monmouth, NJ (US);
Srinath Kasturirangan, Gaithersburg, MD (US);
MedImmune, LLC, Gaithersburg, MD (US);
Abstract
The present invention relates to anti-HER2 binding molecules (e.g., antibodies and antigen binding fragments thereof), derived HER2-binding molecules (e.g., bispecific anti-HER2 antibodies), and antibody-drug conjugates (ADC) that bind the extracellular domain of the HER2 receptor. Also provided are pharmaceutical formulation comprising the disclosed compositions and method for the treating diseases associated with HER2-mediated signal transduction.