The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2018
Filed:
Jun. 03, 2015
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.l.a. China, Beijing, CN;
Wu Zhong, Beijing, CN;
Song Li, Beijing, CN;
Shuang Cao, Beijing, CN;
Ruiyuan Cao, Beijing, CN;
Junhai Xiao, Beijing, CN;
Xinbo Zhou, Beijing, CN;
Xingzhou Li, Beijing, CN;
Abstract
The present invention pertains to the field of pharmaceutical chemicals, and relates to a rapamycin derivative of Formula I, and a preparation method, pharmaceutical composition and use thereof. The compounds of the present invention overcome the defects of rapamycin in terms of water solubility and metabolic properties, and some of the compounds have an in vitro anti-tumor activity superior to rapamycin, have less toxicity to normal cells than rapamycin, and have very good druggability.