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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10160747 B1

PDFFull Text
Date of Patent:
Dec. 25, 2018

Filed:

Mar. 15, 2017

Compounds and methods for kinase modulation, and indications therefor

Applicant:

Plexxikon Inc., Berkeley, CA (US);

Inventors:

Jack Lin, Hercules, CA (US);

Prabha N. Ibrahim, Mountain View, CA (US);

Aaron Albers, San Francisco, CA (US);

John Buell, San Francisco, CA (US);

Zuojun Guo, Pasadena, CA (US);

Phuongly Pham, San Francisco, CA (US);

Hannah Powers, San Francisco, CA (US);

Songyuan Shi, Fremont, CA (US);

Wayne Spevak, Berkeley, CA (US);

Guoxian Wu, Foster City, CA (US);

Jiazhong Zhang, Foster City, CA (US);

Ying Zhang, Fremont, CA (US);

Jeffrey Wu, Berkeley, CA (US);

Assignee:

Plexxikon Inc., Berkeley, CA (US);

Attorney:

Sheppard Mullin Richter & Hampton LLP

Primary Examiner:

Alexander R Pagano

Int. Cl.
CPC ...
A61K 31/506 (2006.01); C07D 401/14 (2006.01); A61K 31/437 (2006.01); A61K 31/444 (2006.01); A61K 31/4985 (2006.01); A61K 31/5355 (2006.01); A61K 45/06 (2006.01); C07D 401/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 498/04 (2006.01); C07D 417/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/5355 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 417/04 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 498/04 (2013.01);
Abstract

Disclosed are compounds of Formula I(b): or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Ring A, Ring HD, J, each T, R, R, R, each R, and m are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

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