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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10160726 B1

PDFFull Text
Date of Patent:
Dec. 25, 2018

Filed:

Aug. 03, 2015

Quinolone derivatives as antibacterials

Applicant:

Novartis Ag, Basel, CH;

Inventors:

Javier de Vicente Fidalgo, Foster City, CA (US);

Haiying He, Shanghai, CN;

Cheng Hu, San Mateo, CA (US);

Zhigan Jiang, Shanghai, CN;

Xiaolin Li, Alameda, CA (US);

Peichao Lu, Pleasant Hill, CA (US);

Wosenu Mergo, Oakland, CA (US);

Daniel Mutnick, Concord, CA (US);

Folkert Reck, Walnut Creek, CA (US);

Alexey Rivkin, Emeryville, CA (US);

Colin Keith Skepper, Alameda, CA (US);

Xiaojing Michael Wang, Livermore, CA (US);

Jianhua Xia, Shanghai, CN;

Yongjin Xu, Castro Valley, CA (US);

Assignee:

Novartis AG, Basel, CH;

Attorney:

Mark H. Hopkins

Primary Examiner:

D Margaret M Seaman

Int. Cl.
CPC ...
C07D 215/38 (2006.01); C07D 215/22 (2006.01); A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/5386 (2006.01); A61K 45/06 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 419/14 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01); C07D 487/10 (2006.01); C07D 498/10 (2006.01);
U.S. Cl.
CPC ...
C07D 215/38 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 31/5386 (2013.01); A61K 45/06 (2013.01); C07D 215/22 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 419/14 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 487/10 (2013.01); C07D 498/10 (2013.01);
Abstract

This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.

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