The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 18, 2018

Filed:

Aug. 31, 2016
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Elliot L. Botvinick, Irvine, CA (US);

Vasan Venugopalan, Irvine, CA (US);

Jonathan Compton, Irvine, CA (US);

Amy Hellman, Huntington Beach, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); C40B 30/06 (2006.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5032 (2013.01); G01N 33/5064 (2013.01); G01N 33/54373 (2013.01); C40B 30/06 (2013.01);
Abstract

A method and device are disclosed for inducing mechanical stress in a cellular sample to evaluate mechanotransduction in the cellular sample. In one embodiment, the mechanical stress is induced by generating a microcavitation bubble in the cellular sample using a pulsed energy. The microcavitation bubble creates a microtsunami, which provides a transient, impulsive mechanical stress on the cellular sample, forming a gradient of effects at distances away from the microcavitation bubble.


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