The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2018
Filed:
Nov. 14, 2016
Applicant:
Institute of Zoology, Chinese Academy of Sciences, Beijing, CN;
Inventors:
Quan Chen, Beijing, CN;
Baowei Li, Beijing, CN;
Haiying Hang, Beijing, CN;
Lei Du, Beijing, CN;
Jun Wang, Beijing, CN;
Xiaohui Wang, Beijing, CN;
Assignee:
Institute of Zoology, Chinese Academy of Sciences, Beijing, CN;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); C07K 16/32 (2006.01); C07K 16/30 (2006.01); G01N 33/577 (2006.01); C07K 16/28 (2006.01); G01N 33/574 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C07K 16/2863 (2013.01); C07K 16/2872 (2013.01); C07K 16/3046 (2013.01); C07K 16/32 (2013.01); G01N 33/577 (2013.01); G01N 33/57492 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); C07K 2317/24 (2013.01); C07K 2317/34 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/73 (2013.01); G01N 2333/47 (2013.01);
Abstract
A monoclonal antibody against human PrPc protein capable of reducing the expression level of transcription factor Twist1 in a targeting mode and inducing macrophage and NK cells to target to rectal cancer tumor cells. The combined drug therapy with the antibody and cetuximab also exhibits inhibitory effect on tumor better than administration of the antibody or cetuximab alone.