The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2018
Filed:
Jul. 27, 2017
Applicants:
The Trustees of Columbia University IN the City of New York, New York, NY (US);
The Regents of the University of California, Oakland, CA (US);
Inventors:
Lloyd A. Greene, Larchmont, NY (US);
James Angelastro, Davis, CA (US);
Assignees:
The Trustees of Columbia University in the City of New York, New York, NY (US);
The Regents of the University of California, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 38/00 (2006.01); A61K 31/495 (2006.01); A61K 38/17 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4705 (2013.01); A61K 31/495 (2013.01); A61K 38/1709 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating dominant-negative ATF5 ('CP-d/n-ATF5'), wherein the CP-d/n-ATF5 is capable of inhibiting ATF5 function and/or activity.