The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 18, 2018

Filed:

Jan. 07, 2016
Applicant:

Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;

Inventors:

Armin Heckel, Biberach an der Riss, DE;

Dieter Hamprecht, Pozzolengo, IT;

Joerg Kley, Mittelbiberach, DE;

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/12 (2006.01); A61K 31/497 (2006.01); A61K 31/5377 (2006.01); A61K 31/551 (2006.01); A61K 31/675 (2006.01); A61K 45/06 (2006.01); C07C 53/18 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07F 9/53 (2006.01); C07D 403/14 (2006.01); C07F 9/6558 (2006.01); C07F 7/18 (2006.01); A61P 11/00 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); A61P 11/00 (2018.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07F 7/1856 (2013.01); C07F 9/5304 (2013.01); C07F 9/65583 (2013.01);
Abstract

The present invention relates to compounds of formula (I), or the tautomers or pharmacologically acceptable acid addition salts thereof, characterized by a topological polar surface area value (TPSA) of at least 145, wherein R, R, R, R, X, and Zhave one of the meanings as defined in the specification, to the use of compounds of formula (I) as a medicament, to pharmaceutical composition comprising at least one compound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).


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