The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 18, 2018

Filed:

Jul. 29, 2016
Applicants:

Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Lianyungang, Jiangsu Province, CN;

Lianyungang Runzhong Pharmaceutical Co., Ltd., Lianyungang, Jiangsu Province, CN;

Centaurus Biopharma Co., Ltd., Beijing, CN;

Inventors:

Shulong Wang, Beijing, CN;

Na Zhao, Beijing, CN;

Xijie Liu, Beijing, CN;

Yuandong Hu, Beijing, CN;

Hui Zhang, Beijing, CN;

Hong Luo, Beijing, CN;

Yong Peng, Beijing, CN;

Dengming Xiao, Beijing, CN;

Yongxin Han, Beijing, CN;

Xiquan Zhang, Lianyungang, CN;

Xin Tian, Lianyungang, CN;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 275/42 (2006.01); C07D 231/12 (2006.01); C07D 333/20 (2006.01); C07D 333/24 (2006.01); C07D 409/10 (2006.01); C07D 409/12 (2006.01); C07D 213/56 (2006.01); A61P 35/02 (2006.01);
U.S. Cl.
CPC ...
C07C 275/42 (2013.01); A61P 35/02 (2018.01); C07D 213/56 (2013.01); C07D 231/12 (2013.01); C07D 333/20 (2013.01); C07D 333/24 (2013.01); C07D 409/10 (2013.01); C07D 409/12 (2013.01);
Abstract

The present application relates to compounds represented by general formula (I), general formula (II) or general formula (III), and pharmaceutically acceptable salts or hydrates thereof, preparation methods thereof, and pharmaceutical compositions thereof. The compounds represented by general formula (I), general formula (II) or general formula (III) have inhibitory activities against isocitrate dehydrogenase 2 (IDH2), thereby being capable of treating IDH2 mutation-induced cancers.


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