The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2018
Filed:
Feb. 27, 2017
Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins
Applicants:
Institut Pasteur, Paris, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Inventors:
Assignees:
INSTITUT PASTEUR, Paris, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris, FR;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); A61K 47/68 (2017.01); A61K 51/10 (2006.01); C07K 16/30 (2006.01); C12N 5/079 (2010.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 51/1018 (2013.01); C07K 16/18 (2013.01); C07K 16/3053 (2013.01); C12N 5/0622 (2013.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); A61K 2039/543 (2013.01); A61K 2039/545 (2013.01); C07K 2317/22 (2013.01); C07K 2317/569 (2013.01); C07K 2317/92 (2013.01);
Abstract
The present invention relates to the use of variable domains of camelid heavy-chain antibodies (VHH domains) directed against an intracellular target and having an isoelectric point of at least 8.5, for targeting said intracellular target or for the preparation of a peptide vector. Particularly, it concerns VHH domains directed against a glial fibrillary acidic protein and uses thereof for preparing therapeutic or diagnostic agents.