The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 11, 2018

Filed:

Mar. 24, 2016
Applicant:

Mcmaster University, Hamilton, CA;

Inventors:

John D. Brennan, Dundas, CA;

Yingfu Li, Dundas, CA;

Carmen Carrasquilla, Hamilton, CA;

Assignee:

MCMASTER UNIVERSITY, Hamilton, CA;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12Q 1/6818 (2018.01); C12Q 1/6825 (2018.01); C12Q 1/6834 (2018.01); G01N 33/53 (2006.01); C12Q 1/6816 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6818 (2013.01); C12Q 1/6816 (2013.01); C12Q 1/6825 (2013.01); C12Q 1/6834 (2013.01); G01N 33/5308 (2013.01);
Abstract

The present application relates to biosensors, for example comprising an high-molecular weight, tandem repeating, structure-switching nucleic acid aptamers (concatemeric aptamers) to rapidly create patterned sensors via, for example, inkjet printing. These concatemeric aptamer reporters remain immobilized at the point of printing through strong adsorption but retain sufficient segmental mobility to undergo structure switching and reporter signalling to provide both qualitative and quantitative detection of one or more analytes. In certain embodiments, inkjet printing allows for the patterning of internally referenced sensors with multiplexed detection, and provides a generic platform for on-demand printing of sensors even in remote locations.


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