The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2018
Filed:
Aug. 31, 2011
Applicants:
Robert J. Dunn, San Diego, CA (US);
Marilyn R. Kehry, San Diego, CA (US);
Inventors:
Robert J. Dunn, San Diego, CA (US);
Marilyn R. Kehry, San Diego, CA (US);
Assignee:
Biogen MA Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/42 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/4258 (2013.01); C07K 16/2887 (2013.01); C07K 16/4208 (2013.01); C07K 2317/52 (2013.01);
Abstract
The present disclosure relates to in vivo methods for producing anti-idiotypic antibodies. In some aspects, anti-idiotypic antibodies are generated by co-administering to a mouse a first antibody having a murine IgG2a isotype and a second antibody that targets mouse B cells and has a murine IgG2a isotype. In some embodiments, the mouse expresses the Igh-1allele of IgG2a, and the second antibody binds a mouse B cell surface marker selected from the group consisting of CD19, CD20, CD21, CD22, CD40, CD45, IgM, and IgD.