The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2018
Filed:
Dec. 30, 2014
Jean-pierre Robin, Geneva, CH;
Nina Radosevic, Geneva, CH;
Julie Blanchard, Puyricard, FR;
Thierry Roisnel, Thorigne-Fouillard, FR;
Thierry Bataille, Thorigne-Fouillard, FR;
Jean-Pierre Robin, Geneva, CH;
Nina Radosevic, Geneva, CH;
Julie Blanchard, Puyricard, FR;
Thierry Roisnel, Thorigne-Fouillard, FR;
Thierry Bataille, Thorigne-Fouillard, FR;
Other;
Abstract
The present disclosure concerns harringtonines salts at the crystalline state exhibiting a protonated nitrogen seen in solid state analysis and having general formula 1, in which R1 is, but not limited to, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocycloalkyl, and R2 is, independently, but not limited to H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocycloalkyl, with an acid having general formula AH in a non-aqueous crystallization solvent, wherein the said salt has a large water solubility. The disclosure is also related to a process for preparing and purifying these salts and their use as chemotherapeutic drugs.