The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 11, 2018

Filed:

Feb. 02, 2016
Applicant:

Novassay S.a., Epalinges, CH;

Inventors:

Rhonan Lee Ford, Ongar, GB;

Premji Meghani, Loughborough, GB;

Assignee:

Novassay S.A., Epalinges, CH;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 45/85 (2006.01); C07D 257/04 (2006.01); C07B 57/00 (2006.01); A61P 25/00 (2006.01); C07B 43/02 (2006.01); C07B 43/08 (2006.01); C07B 63/02 (2006.01); C07C 49/627 (2006.01); C07D 207/06 (2006.01); C07D 211/32 (2006.01);
U.S. Cl.
CPC ...
C07C 45/85 (2013.01); A61P 25/00 (2018.01); C07B 43/02 (2013.01); C07B 43/08 (2013.01); C07B 57/00 (2013.01); C07B 63/02 (2013.01); C07C 49/627 (2013.01); C07D 257/04 (2013.01); C07C 2602/20 (2017.05); C07D 207/06 (2013.01); C07D 211/32 (2013.01);
Abstract

A process to isolate a compound of Formula (2a) or a salt or solvate thereof, comprising a) reacting a mixture of diastereoisomers of Formulae (2a, 2b) with a basic heterocyclic-aldehyde compound and an optically active amine in the presence of a base; and b) separating the compound of Formula (2a) from the product of step a) by acid extraction. The compound of Formula (2a) may be produced with an enantiomeric excess of 98%. Compounds of Formula (2a) are useful intermediates in a process to prepare a bicyclic γ-amino tetrazole derivative of Formula (I) which finds utility in treating neuropathic pain and disorders of the central nervous system.


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