The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2018
Filed:
Mar. 28, 2016
Applicant:
Rutgers, the State University of New Jersey, New Brunswick, NJ (US);
Inventor:
Scott Kachlany, Bridgewater, NJ (US);
Assignee:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, New Brunswick, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/16 (2006.01); A61K 45/06 (2006.01); A61K 39/395 (2006.01); A61K 31/136 (2006.01); A61K 31/196 (2006.01); A61K 31/198 (2006.01); G01N 33/574 (2006.01); G01N 33/50 (2006.01); G01N 33/569 (2006.01); A61K 31/704 (2006.01); A61K 31/7068 (2006.01); A61K 31/7076 (2006.01);
U.S. Cl.
CPC ...
A61K 38/164 (2013.01); A61K 31/136 (2013.01); A61K 31/196 (2013.01); A61K 31/198 (2013.01); A61K 31/704 (2013.01); A61K 31/7068 (2013.01); A61K 31/7076 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); G01N 33/5052 (2013.01); G01N 33/56972 (2013.01); G01N 33/574 (2013.01); G01N 2800/52 (2013.01); G01N 2800/709 (2013.01); G01N 2800/7095 (2013.01); Y10S 530/825 (2013.01);
Abstract
The invention relates to pharmaceutical compositions comprising leukotoxin, including methods to treat lymphoma, and methods to diagnose lymphoma. The lymphoma includes lymphoma cells expressing activated LFA-1, and the leukotoxin binds to the activated LFA-1 on the lymphoma cells and destroys the lymphoma cells by apoptosis or necrosis, thereby treating said lymphoma.