The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 11, 2018

Filed:

Dec. 14, 2015
Applicant:

Shenyang Sunshine Pharmaceutical Co. Ltd., Shenyang, Liaoning, CN;

Inventors:

Yunlong Zhou, Nanjing, CN;

Suixiong Cai, San Diego, CA (US);

Guangfeng Wang, Shanghai, CN;

Lingling Jiao, Taizhou, CN;

Ping Min, Shanghai, CN;

Yu Jing, Taizhou, CN;

Ming Guo, San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); A61K 31/4412 (2006.01); A61K 31/44 (2006.01); C07D 213/81 (2006.01); A61P 7/06 (2006.01); A61P 19/02 (2006.01); A61K 45/06 (2006.01); C07D 213/65 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4412 (2013.01); A61K 31/44 (2013.01); A61K 45/06 (2013.01); A61P 7/06 (2018.01); A61P 19/02 (2018.01); C07D 213/65 (2013.01); C07D 213/81 (2013.01); Y02P 20/55 (2015.11);
Abstract

A compound of the following formula (I) or a pharmaceutically acceptable salt thereof, wherein Rand Rare independently H; Ris selected from H, a C-Cstraight-chain, and a branched or cyclic alkyl; and R, R, R, R, and Rare each independently selected from C-Calkyl, halo C-Calkyl and the like. Also provided is a method for preparing the compound, pharmaceutical compositions including the compound or pharmaceutically acceptable salts thereof, and uses of the compound or pharmaceutically acceptable salt thereof in the preparation of a medicine for inhibiting HIF prolyl hydroxylase or a medicine for promoting the generation of endogenous EPO.


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