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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10149644 B1

PDFFull Text
Date of Patent:
Dec. 11, 2018

Filed:

Oct. 16, 2014

Curcumin derivatives for amyloid-β plaque imaging

Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Chongzhao Ran, Winchester, MA (US);

Anna Moore, Stoneham, MA (US);

Assignee:

The General Hospital Corporation, Boston, MA (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Michael G Hartley

Assistant Examiner:

Sean R Donohue

Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); A61B 5/00 (2006.01); A61K 49/00 (2006.01); A61K 51/04 (2006.01); G01N 33/68 (2006.01); A61B 5/145 (2006.01); A61B 5/1455 (2006.01); A61B 6/03 (2006.01); A61M 5/00 (2006.01); G01R 33/56 (2006.01);
U.S. Cl.
CPC ...
A61B 5/4088 (2013.01); A61B 5/1455 (2013.01); A61B 5/14546 (2013.01); A61B 6/037 (2013.01); A61K 49/0002 (2013.01); A61K 49/0021 (2013.01); A61K 51/0455 (2013.01); A61M 5/007 (2013.01); G01N 33/6896 (2013.01); G01R 33/5601 (2013.01); G01N 2333/4709 (2013.01); G01N 2800/28 (2013.01); G01N 2800/2821 (2013.01);
Abstract

The present invention provides curcumin-derived near infrared (NIR) imaging probes. Upon interacting with amyloid β aggregates, these probes undergo a range of changes, qualifying them as 'smart' probes. The inventors have demonstrated that probes of the invention have the capacity to monitor the progression of Alzheimer's disease in an in vivo animal model. In addition, the present invention encompasses probes useful as PET imaging agents, MRI imaging agents and multimodal imaging agents, as well as related methods of detecting and imaging amyloid β aggregates and plaques.

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