The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2018
Filed:
Jan. 15, 2016
Applicant:
Quark Pharmaceuticals, Inc., Fremont, CA (US);
Inventors:
Sharon Avkin-Nachum, Nes Zionna, IL;
Elena Feinstein, Rehovot, IL;
Leonid Beigelman, San Mateo, CA (US);
Assignee:
Quark Pharmaceuticals, Inc., Fremont, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/111 (2013.01); C12N 2310/14 (2013.01); C12N 2310/319 (2013.01); C12N 2310/323 (2013.01); C12N 2310/344 (2013.01); C12N 2310/346 (2013.01); C12N 2320/50 (2013.01); C12N 2320/51 (2013.01);
Abstract
Disclosed herein are double stranded RNA molecules which have been modified to exhibit one of the following, increased activity, enhanced nuclease stability, reduced off target activity and or reduced immunogenicity, to pharmaceutical compositions comprising such compounds and to methods of use. Further disclosed is a method for the synthesis of threose nucleic acid phosphoramidites and methods of use thereof.