The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2018
Filed:
Oct. 07, 2015
Applicant:
Euticals S.p.a., Milan, IT;
Inventors:
Paride Grisenti, Milan, IT;
Elahi Shahrzad Reza, Milan, IT;
Giuseppe Guazzi, Milan, IT;
Maria Argese, Milan, IT;
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/16 (2006.01); C07H 19/167 (2006.01);
U.S. Cl.
CPC ...
C07H 19/16 (2013.01); C07H 19/167 (2013.01); C07B 2200/13 (2013.01);
Abstract
A process for the preparation of the amorphous form of Regadenoson of formula is disclosed together with new crystalline polymorphic forms E, F and G and methods for their preparation. Regadenoson amorphous form can be prepared in mild reaction conditions with high chemical purity (>99.6%) and high stability to the heating. A particularly thermodynamically stable anhydrous crystalline form of Regadenoson (form G) is also disclosed, provided with high stability not when exposed to 90% RH at 25° C. for 96 hour, but also to the heating up to 200° C.