logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10144742 B1

PDFFull Text
Date of Patent:
Dec. 04, 2018

Filed:

Apr. 17, 2015

Quinoxaline compounds and uses thereof

Applicant:

Millennium Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Kenneth M. Gigstad, Westford, MA (US);

David P. Cardin, Wilmington, MA (US);

Takaharu Hirayama, Kanagawa, JP;

Masaaki Hirose, Tokyo, JP;

Yongbo Hu, Winchester, MA (US);

Hiroyuki Kakei, Kanagawa, JP;

Hong Myung Lee, Cambridge, MA (US);

Takashi Motoyaji, Kanagawa, JP;

Noriyuki Nii, Kanagawa, JP;

Zhan Shi, Concord, MA (US);

Stepan Vyskocil, Arlington, MA (US);

Hiroyuki Watanabe, Hyogo, JP;

Assignee:

Millennium Pharmaceuticals, Inc., Cambridge, MA (US);

Attorney:

McNeill Baur PLLC

Primary Examiner:

Paul V Ward

Int. Cl.
CPC ...
C07D 498/04 (2006.01); C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 401/12 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 491/107 (2006.01); A61K 31/498 (2006.01); A61K 31/4985 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/5375 (2006.01); A61K 31/541 (2006.01); A61K 31/55 (2006.01); A61K 31/553 (2006.01); C07D 491/08 (2006.01); C07D 491/113 (2006.01);
U.S. Cl.
CPC ...
C07D 498/04 (2013.01); A61K 31/498 (2013.01); A61K 31/4985 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5375 (2013.01); A61K 31/541 (2013.01); A61K 31/55 (2013.01); A61K 31/553 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 491/08 (2013.01); C07D 491/107 (2013.01); C07D 491/113 (2013.01);
Abstract

This invention provides compounds of formula I and subsets thereof: wherein T, J, R, R, R, o, R, and Rand subsets thereof are as described in the specification. The compounds are inhibitors of NAMPT and are thus useful for treating cancer, inflammatory conditions, or T-cell mediated autoimmune disease.

Find Patent Forward Citations

Loading…