The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2018
Filed:
Apr. 21, 2015
Applicant:
The Feinstein Institute for Medical Research, Manhasset, NY (US);
Inventors:
Rosamaria Ruggieri, Roslyn Estates, NY (US);
Yousef Al-Abed, Dix Hills, NY (US);
Marc Symons, Roslyn Estates, NY (US);
Assignee:
The Feinstein Institute for Medical Research, Manhasset, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61K 45/06 (2006.01); A61K 31/506 (2006.01); A61K 41/00 (2006.01); A61N 5/10 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/506 (2013.01); A61K 41/0038 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); A61N 2005/1098 (2013.01);
Abstract
Methods and compounds are described for treating solid tumors, and in particular, malignant, neoplastic solid tumors such as glioblastoma and medulloblastoma, by inhibiting protein kinase MRK/ZAK activity. Also provided are pharmaceutical composition containing a MRK/ZAK inhibitor compound and a pharmaceutically acceptable carrier and a method of sensitizing tumor cells to radiation therapy comprising administering an effective amount of the MRK/ZAK inhibitor compound.