The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2018
Filed:
Sep. 21, 2017
Applicant:
U.s. Army Edgewood Chemical Biological Center, APG, MD (US);
Inventors:
Sue Y Bae, Hanover, MD (US);
Mark A. Guelta, White Marsh, MD (US);
Steven P Harvey, Lutherville, MD (US);
Assignee:
The United States of America as Represented by the Secretary of the Army, Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/48 (2006.01); A62D 3/02 (2007.01); C12N 15/03 (2006.01); A62D 101/02 (2007.01); A62D 101/04 (2007.01);
U.S. Cl.
CPC ...
A62D 3/02 (2013.01); C12N 15/03 (2013.01); A62D 2101/02 (2013.01); A62D 2101/04 (2013.01);
Abstract
Disclosed herein are non-wild-type organophosphorus acid anhydrolases having three site mutations, methods of production, and methods of use to effectively degrade toxic chemicals such as((RS)-Propan-2-yl methylphosphonofluoridate)(Sarin) and other organophosphorus compounds. Also provided are organophosphorus acid anhydrolase mutants capable of degrading Sarin with distinct selective stereospecificity preferences differing from the wild-type organophosphorus acid anhydrolase