The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2018
Filed:
Jun. 30, 2011
Applicants:
Sharon Gerecht, Baltimore, MD (US);
Guoming Sun, Baltimore, MD (US);
Yu-i Shen, Baltimore, MD (US);
Inventors:
Assignee:
THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/19 (2006.01); A61L 27/26 (2006.01); A61K 31/721 (2006.01); A61L 27/52 (2006.01); A61K 38/30 (2006.01); A61K 38/18 (2006.01); A61L 27/54 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61L 27/26 (2013.01); A61K 9/0024 (2013.01); A61K 31/721 (2013.01); A61K 38/1866 (2013.01); A61K 38/1891 (2013.01); A61K 38/195 (2013.01); A61K 38/30 (2013.01); A61K 45/06 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 2300/414 (2013.01); A61L 2300/45 (2013.01); A61L 2430/32 (2013.01);
Abstract
Slow vascularization of functional blood limits the transplantation of tissue constructs and the recovery of ischemic and wounded tissues. Blood vessel ingrowth into polysaccharide-based hydrogel scaffolds remains a challenge. A synergistic effect of multiple angiogenic GFs was established; the co-encapsulation of VEGF plus other growth factors induced more and larger blood vessels than any individual GF, while the combination of all GFs dramatically increased the size and number of newly formed functional vessels. Rapid, efficient, and functional neovascularization may be achieved.