The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2018
Filed:
Mar. 11, 2015
Yale University, New Haven, CT (US);
Albert Ko, New Haven, CT (US);
Elsio Wunder, Wallingford, CT (US);
Yale University, New Haven, CT (US);
Abstract
The present invention includes compositions and methods of preparing flagellar-coiling protein 1 (Fcp1)-deficientbacterium. In one aspect, the invention includes an isolated, flagellar-coiling protein 1 (Fcp1)-deficientbacterium. Another aspect includes a composition comprising a flagellar-coiling protein 1 (Fcp1) deficientbacterium. Yet another aspect includes a method of producing a motility-deficientbacterium comprising inhibiting expression of a wild-type flagellar-coiling protein 1 (Fcp1) gene. Methods of stimulating an immune response and reducing or treating an infectious disease caused by one or morebacteria in a subject in need thereof comprising administering a composition comprising an effective amount of flagellar-coiling protein 1 (Fcp1) deficientbacteria to the subject are also included.