The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2018
Filed:
Aug. 21, 2017
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Dong-Ming Shen, Edison, NJ (US);
Rongze Kuang, Green Brook, NJ (US);
Puneet Kumar, Edison, NJ (US);
Joseph L. Duffy, Cranford, NJ (US);
Cheng Zhu, Edison, NJ (US);
Amjad Ali, Freehold, NJ (US);
Meng Yang, Edison, NJ (US);
John S. Debenham, Scotch Plains, NJ (US);
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4412 (2006.01); C07D 213/89 (2006.01); A61K 31/435 (2006.01);
U.S. Cl.
CPC ...
A61K 31/435 (2013.01); C07D 213/89 (2013.01); A61K 2121/00 (2013.01);
Abstract
The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.