The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 04, 2018

Filed:

May. 29, 2015
Applicants:

Board of Regents of the University of Texas System, Austin, TX (US);

The Ohio State University Research Foundation, Columbus, OH (US);

Inventors:

Mauro Ferrari, Houston, TX (US);

Ennio Tasciotti, Houston, TX (US);

Jason Sakamoto, Houston, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01); A61K 31/165 (2006.01); A61K 31/704 (2006.01); A61K 31/7088 (2006.01);
U.S. Cl.
CPC ...
A61K 9/50 (2013.01); A61K 9/127 (2013.01); A61K 9/1271 (2013.01); A61K 9/51 (2013.01); A61K 31/165 (2013.01); A61K 31/704 (2013.01); A61K 31/7088 (2013.01);
Abstract

Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.


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