The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 27, 2018

Filed:

Sep. 15, 2016
Applicant:

Advanced Liquid Logic, Inc., San Diego, CA (US);

Inventors:

Vamsee K. Pamula, Cary, NC (US);

Ramakrishna Sista, Cary, NC (US);

Vijay Srinivasan, Cary, NC (US);

Michael G. Pollack, Durham, NC (US);

Allen Eckhardt, San Diego, CA (US);

Assignee:

ADVANCED LIQUID LOGIC, INC., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); G01N 1/00 (2006.01); G01N 1/10 (2006.01); G01N 15/06 (2006.01); G01N 1/18 (2006.01); G01N 33/543 (2006.01); B01F 11/00 (2006.01); B01F 13/00 (2006.01); G01N 1/38 (2006.01); B01F 13/08 (2006.01); B01L 7/00 (2006.01); G01N 35/10 (2006.01);
U.S. Cl.
CPC ...
G01N 33/54326 (2013.01); B01F 11/0071 (2013.01); B01F 13/0071 (2013.01); B01F 13/0076 (2013.01); B01F 13/0809 (2013.01); B01L 3/50273 (2013.01); B01L 3/502761 (2013.01); B01L 3/502792 (2013.01); G01N 1/38 (2013.01); B01L 7/52 (2013.01); B01L 7/525 (2013.01); B01L 2200/027 (2013.01); B01L 2200/0647 (2013.01); B01L 2200/0673 (2013.01); B01L 2300/06 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/089 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0861 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/1827 (2013.01); B01L 2400/043 (2013.01); B01L 2400/0406 (2013.01); B01L 2400/0415 (2013.01); B01L 2400/0421 (2013.01); B01L 2400/0424 (2013.01); B01L 2400/0427 (2013.01); B01L 2400/0436 (2013.01); B01L 2400/0442 (2013.01); G01N 2001/386 (2013.01); G01N 2035/1046 (2013.01); Y10T 436/11 (2015.01); Y10T 436/25 (2015.01); Y10T 436/2575 (2015.01); Y10T 436/25625 (2015.01);
Abstract

The invention provides a method of circulating magnetically responsive beads within a droplet in a droplet actuator. The invention also provides methods for splitting droplets. The invention, in one embodiment, makes use of a droplet actuator with top and bottom substrates, a plurality of magnetic fields respectively present proximate the top and bottom substrates, wherein at least one of the magnet fields is selectively alterable, and a plurality of droplet operations electrodes positioned along at least one of the top and bottom surfaces. A droplet is positioned between the top and bottom surfaces and at least one of the magnetic fields is selectively altered.


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