The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2018
Filed:
Nov. 02, 2017
Applicant:
Calimmune, Inc., Tucson, AZ (US);
Inventors:
Chi-Lin Lee, Arcadia, CA (US);
Jeffrey S Bartlett, Columbus, OH (US);
Assignee:
Calimmune, Inc., Tucson, AZ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C12N 15/00 (2006.01); C12N 15/86 (2006.01); A01K 67/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2740/15043 (2013.01); C12N 2740/16041 (2013.01); C12N 2740/16043 (2013.01); C12N 2740/16052 (2013.01); C12N 2800/107 (2013.01); C12N 2800/70 (2013.01); C12N 2830/006 (2013.01); C12N 2830/40 (2013.01);
Abstract
The present disclosure provides a method of generating a stable producer cell line. The generation of stable producer cell lines, such as those provided in accordance with the present invention, increases the reproducibility and ease of creating high titer lentiviral stocks while easing biosafety concerns and the variation in expressed envelope proteins defines the tropism of the generated virus. The present disclosure also provides for a novel lentiviral transfer vector plasmid.