The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 27, 2018

Filed:

Sep. 23, 2015
Applicant:

Mallinckrodt Hospital Products Ip Limited, Dublin, IE;

Inventors:

David Peritt, Bala Cynwyd, PA (US);

Kim Campbell, Downingtown, PA (US);

Amy Krutsick, Chester Springs, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); A61K 31/366 (2006.01); A61K 31/59 (2006.01); A61K 35/17 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0637 (2013.01); A61K 31/366 (2013.01); A61K 31/59 (2013.01); A61K 35/17 (2013.01); C12N 5/0636 (2013.01); C12N 2500/38 (2013.01); C12N 2501/15 (2013.01); C12N 2501/23 (2013.01); C12N 2501/231 (2013.01); C12N 2501/39 (2013.01); C12N 2502/11 (2013.01);
Abstract

Many cell types in the body can remove apoptotic and cellular debris from tissues; however, the professional phagocyte, or antigen presenting cell ('APC'), has a high capacity to do so. The recognition of apoptotic cells ('ACs') occurs via a series of evolutionarily-conserved, AC associated molecular-pattern receptors (“ACAMPRs”) on APCs that recognize and bind corresponding apoptotic-cell-associated molecular patterns (“ACAMPs”). These receptors recognize ligands such as phosphotidyl serine and oxidized lipids found on apoptotic cells. Savill et al. (2002); and Gregory et al. (2004).


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Peritt, David. (2018). Use of apoptotic cells ex vivo to generate regulatory t cells (U.S. Patent No. 10138464). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10138464

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