The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2018
Filed:
Jan. 05, 2016
Delphi Genetics SA, Charleroi, BE;
Jean-Christophe Renauld, Kraainem, BE;
Muriel Lemaire, Ottignies, BE;
Laurie Dumoutier, Orbais, BE;
Yannick Nizet, Lincent, BE;
Alain Vanderplasschen, Tubize, BE;
Laurent Gillet, Tenneville, BE;
Sophie Scohy, Nivelles, BE;
CĂ©dric Szpirer, Fleurus, BE;
Delphi Genetics S.A., Sharleroi (Gosselies), BE;
Abstract
Methods are disclosed for generating antibodies and an expression vector used to express protein(s) which provoke the antibody response. The expression vector may be useful in generating an antibody directed to an antigen, comprising a gene in operable linkage with a promoter, which gene encodes upon expressing a fusion protein comprising (i) CD134L, a fragment, homologous or orthologues protein thereof as N-terminal moiety of the fusion protein; and (ii) all or part of an antigenic protein as C-terminal moiety of the fusion protein. To generate the antibodies, the vector is injected into a subject animal, which produces a fusion protein, against which antibodies are generated.