The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2018
Filed:
May. 21, 2015
Applicants:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Janssen Biotech, Inc., Horsham, PA (US);
Inventors:
C. Cheng Kao, Bloomington, IN (US);
Divyendu Singh, Bloomington, IN (US);
Lani Rose San Mateo, Devon, PA (US);
Assignee:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 38/17 (2006.01); A61K 31/505 (2006.01); A61K 31/7036 (2006.01); A61K 31/704 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4723 (2013.01); A61K 31/505 (2013.01); A61K 31/704 (2013.01); A61K 31/7036 (2013.01); A61K 38/1729 (2013.01); A61K 45/06 (2013.01);
Abstract
This disclosure is related to the peptide antagonist of LL-37, an antimicrobial peptide that has multiple functions in both innate and adaptive immune response. Specifically, the identified peptide antagonists of LL-37 provide inhibition to detrimental autoimmune inflammatory response, whereas at the same time retain LL-37's antibacterial activity.