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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10138251 B1

PDFFull Text
Date of Patent:
Nov. 27, 2018

Filed:

Apr. 10, 2015

Spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors

Applicant:

Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;

Inventors:

Andreas Gollner, Vienna, AT;

Christiane Kofink, Perchtoldsdorf, AT;

Juergen Ramharter, Vienna, AT;

Harald Weinstabl, Vienna, AT;

Tobias Wunberg, Hinterbruehl, AT;

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorney:

Edouard G. Lebel

Primary Examiner:

Rita J Desai

Int. Cl.
CPC ...
C07D 487/20 (2006.01); A61K 31/407 (2006.01); C07D 471/22 (2006.01); A61K 31/437 (2006.01); C07D 487/10 (2006.01); A61K 45/06 (2006.01); A61K 31/4439 (2006.01);
U.S. Cl.
CPC ...
C07D 487/20 (2013.01); A61K 31/407 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 45/06 (2013.01); C07D 471/22 (2013.01); C07D 487/10 (2013.01);
Abstract

The present invention encompasses compounds of formula (I) wherein the groups Rto R, V, W, X, Y, n and q are defined herein, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases and synthetic intermediates.

Find Patent Forward Citations

Gollner, Andreas. (2018). Spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors (U.S. Patent No. 10138251). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10138251

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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