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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10138230 B1

PDFFull Text
Date of Patent:
Nov. 27, 2018

Filed:

Feb. 04, 2016

Autotaxin inhibitors

Applicant:

Cancer Research Technology Limited, London, GB;

Inventors:

Francesca Blum, Cambridge, GB;

James Lindsay Carr, Cambridge, GB;

Pritom Shah, Cambridge, GB;

Maria Del Mar Jimenez Quesada, Cambridge, GB;

Irene Farre Gutierrez, Cambridge, GB;

Assignee:

Cancer Research Technology Limited, London, GB;

Attorney:

Mintz Levin Cohn Ferris Glovsky and Popeo PC

Primary Examiner:

Erich A Leeser

Int. Cl.
CPC ...
C07D 417/14 (2006.01); C07D 413/14 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 417/12 (2006.01); C07D 413/12 (2006.01); C07D 405/14 (2006.01); A61K 31/454 (2006.01); A61K 31/5377 (2006.01); A61K 31/433 (2006.01); A61K 31/496 (2006.01); A61K 31/551 (2006.01); A61K 31/55 (2006.01); A61K 31/553 (2006.01); A61K 31/501 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); A61K 31/433 (2013.01); A61K 31/454 (2013.01); A61K 31/496 (2013.01); A61K 31/501 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 31/551 (2013.01); A61K 31/553 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01);
Abstract

The present invention relates to compounds of formula (I): wherein R, R, R, R, R, R, R, L, A, Q, W and HET are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.

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