The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2018
Filed:
Jul. 15, 2016
Applicant:
University Health Network, Toronto, CA;
Inventors:
Jeffrey A. Medin, Shorewood, WI (US);
Sean Devine, Toronto, CA;
Assignee:
University Health Network, Toronto, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01); C12N 15/85 (2006.01); C12N 15/86 (2006.01); C07H 21/04 (2006.01); A61K 48/00 (2006.01); C07K 14/705 (2006.01); C12N 9/12 (2006.01); C12N 5/16 (2006.01); C12N 15/864 (2006.01); C12N 15/861 (2006.01); C12N 15/867 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0058 (2013.01); C07K 14/70503 (2013.01); C12N 9/1229 (2013.01); C12N 15/86 (2013.01); C12Y 207/04009 (2013.01); A61K 38/00 (2013.01); C07H 21/04 (2013.01); C07K 2319/00 (2013.01); C12N 5/16 (2013.01); C12N 15/63 (2013.01); C12N 15/85 (2013.01); C12N 15/861 (2013.01); C12N 15/867 (2013.01); C12N 15/8645 (2013.01); C12N 2740/15041 (2013.01); C12N 2740/15043 (2013.01); C12N 2740/16043 (2013.01); C12N 2840/203 (2013.01);
Abstract
The application relates to a composition comprising a stably integrating delivery vector, a modified mammalian thymidylate kinase (tmpk) that increases phosphorylation of a prodrug relative to phosphorylation of the prodrug by wild-type human tmpk, and a detection cassette fused to the tmpk. The application also relates to use of these compositions in methods of treatment of diseases, such as graft versus host disease and cancer.