The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2018
Filed:
Feb. 05, 2014
University of Georgia Research Foundation, Inc., Athens, GA (US);
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Thermo Fisher Scientific Inc., Waltham, MA (US);
Jon Michael Karpilow, Boulder, CO (US);
Mark Steven Oberste, Johns Creek, GA (US);
Ralph A. Tripp, Watkinsville, GA (US);
Stephen M. Tompkins, Watkinsville, GA (US);
University of Georgia Research Foundation, Inc., Athens, GA (US);
The United States of America, as represented by the Secretary, Dept. of Health and Human Services, Washington, DC (US);
Thermo Fisher Scientific, Inc., Waltham, MA (US);
Abstract
Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picornavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.