The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 27, 2018

Filed:

Jan. 21, 2015
Applicants:

Oregon Health & Science University, Portland, OR (US);

The United States of America As Respresented BY the Department of Veterans Affairs, Washington, DC (US);

Inventors:

Owen J. McCarty, Portland, OR (US);

Norah Verbout, Vancouver, WA (US);

Halina Offner-Vandenbark, Portland, OR (US);

Erik I. Tucker, Portland, OR (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/48 (2006.01); A61K 38/17 (2006.01); A61K 9/00 (2006.01); A61K 38/16 (2006.01);
U.S. Cl.
CPC ...
A61K 38/4833 (2013.01); A61K 9/0019 (2013.01); A61K 38/16 (2013.01); A61K 38/177 (2013.01);
Abstract

Methods of treating neuroinflammation by administration of a selective protein C activator, such as recombinant human WE thrombin and optionally one or more of its cofactors are disclosed. Also disclosed are pharmaceutical compositions for use in the treatment of mammals that exhibit symptoms of neurological inflammation. The pharmaceutical compositions and pharmacological dose comprise a safe and effective amount of WE thrombin.


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