The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 20, 2018
Filed:
Aug. 04, 2011
Thomas F. Tedder, Durham, NC (US);
Takashi Matsushita, Ishikawa, JP;
Yohei Iwata, Magoya, JP;
Koichi Yanaba, Tokyo, JP;
Jean-david Bouaziz, Maison-Alfort, FR;
Thomas F. Tedder, Durham, NC (US);
Takashi Matsushita, Ishikawa, JP;
Yohei Iwata, Magoya, JP;
Koichi Yanaba, Tokyo, JP;
Jean-David Bouaziz, Maison-Alfort, FR;
Duke University, Durham, NC (US);
Abstract
The present invention relates to a distinct B cell subset, B10 cells, that regulate T cell mediated inflammatory responses through the secretion of interleukin-10 (IL-10). The invention also relates to the use of B10 cells in the manipulation of immune and inflammatory responses, and in the treatment of disease. Therapeutic approaches involving adoptive transfer of B10 cells, or expansion of their endogenous levels for controlling autoimmune or inflammatory diseases and conditions are described. Ablation of B10 cells, or inhibition of their IL-10 production can be used to upregulate immunodeficient conditions, ameliorate infectious diseases and/or to treat tumors/cancer. Diagnostic applications are also encompassed.