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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10131786 B1

PDFFull Text
Date of Patent:
Nov. 20, 2018

Filed:

Jul. 13, 2012

Poly((lactic-co-glycolic acid)-b-lysine) and process for synthesizing a block copolymer of plga {poly(lactic-co-glycolic acid)} and pll (poly-ϵ-cbz-l-lysine)

Applicants:

John Harvey, Upton, MA (US);

Daniel Siegwart, Cambridge, MA (US);

Heng Lian Huang, Roxbury Crossing, MA (US);

Brian Hess, Charlestown, MA (US);

Alex Aimetti, Waltham, MA (US);

Inventors:

John Harvey, Upton, MA (US);

Daniel Siegwart, Cambridge, MA (US);

Heng Lian Huang, Roxbury Crossing, MA (US);

Brian Hess, Charlestown, MA (US);

Alex Aimetti, Waltham, MA (US);

Assignees:

INVIVO THERAPEUTICS CORPORATION, Cambridge, MA (US);

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US);

Attorneys:

Pierce Atwood LLP

Raymond G. Arner

Primary Examiner:

Ana L Woodward

Int. Cl.
CPC ...
C08G 81/00 (2006.01); C08L 67/08 (2006.01); A61K 47/42 (2017.01); C08G 63/08 (2006.01); C08L 101/16 (2006.01); C08G 69/08 (2006.01); C08G 69/10 (2006.01); C08G 69/48 (2006.01); C08L 77/04 (2006.01); A61K 47/34 (2017.01);
U.S. Cl.
CPC ...
C08L 67/08 (2013.01); A61K 47/34 (2013.01); A61K 47/42 (2013.01); C08G 63/08 (2013.01); C08G 69/08 (2013.01); C08G 69/10 (2013.01); C08G 69/48 (2013.01); C08G 81/00 (2013.01); C08L 77/04 (2013.01); C08L 101/16 (2013.01); C08L 2203/02 (2013.01);
Abstract

A method of synthesizing copolymers is provided. The method can include coupling a degradable polymer to a poly(amino acid) and then deprotecting the copolymer if the poly(amino acid) contains protected side chains. Copolymer compositions are provided. These compositions include PLGA-PLL copolymers, PLGA-PLL-cbz copolymers, and copolymers of a polyester with a carboxylic acid end group coupled to a poly(amino acid) with an amine group. The compositions may include therapeutic blends and formulations of copolymers.

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