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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10131655 B1

PDFFull Text
Date of Patent:
Nov. 20, 2018

Filed:

Sep. 19, 2016

Substituted heterocyclic acetamides as kappa opioid receptor (kor) agonists

Applicant:

Dr. Reddy's Laboratories Ltd., Hyderabad, Telangana, IN;

Inventors:

Pradip Kumar Sasmal, Hyderabad, IN;

Chintakunta Vamseekrishna, Hyderabad, IN;

Vijay Potluri, Hyderabad, IN;

Ashok Tehim, Ridgewood, NJ (US);

Yonghua Gai, Irvine, CA (US);

Hang Zhang, Beijing, CN;

Assignee:

DR. REDDY'S LABORATORIES, LTD., Hyderabad, Telangana, IN;

Attorneys:

Stites & Harbison, PLLC

Mandy Wilson Decker

Sean P. Ritchie

Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
A61K 31/428 (2006.01); A61K 31/404 (2006.01); A61K 31/423 (2006.01); A61K 31/4704 (2006.01); A61K 31/4709 (2006.01); A61K 31/498 (2006.01); A61K 31/538 (2006.01); A61K 31/5415 (2006.01); C07D 417/14 (2006.01); C07D 241/52 (2006.01); C07D 403/12 (2006.01); C07D 413/14 (2006.01); C07D 401/12 (2006.01); C07D 403/14 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 215/227 (2006.01); C07D 263/58 (2006.01); C07D 265/36 (2006.01); C07D 275/06 (2006.01); C07D 277/68 (2006.01); C07D 209/34 (2006.01); C07D 279/16 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); A61K 31/404 (2013.01); A61K 31/423 (2013.01); A61K 31/428 (2013.01); A61K 31/4704 (2013.01); A61K 31/4709 (2013.01); A61K 31/498 (2013.01); A61K 31/538 (2013.01); A61K 31/5415 (2013.01); C07D 209/34 (2013.01); C07D 215/227 (2013.01); C07D 241/52 (2013.01); C07D 263/58 (2013.01); C07D 265/36 (2013.01); C07D 275/06 (2013.01); C07D 277/68 (2013.01); C07D 279/16 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01);
Abstract

The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. wherein R, R, R, R, R, and Rare as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

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