The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 20, 2018

Filed:

Aug. 05, 2015
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Harry Chobanian, Aberdeen, NJ (US);

Duane DeMong, Hanover, MA (US);

Christopher W. Plummer, Hoboken, NJ (US);

Minghai Fang, Shanghai, CN;

Bin Hu, Shanghai, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 405/14 (2006.01); C07D 405/04 (2006.01); C07D 405/10 (2006.01); C07D 313/08 (2006.01); A61K 45/06 (2006.01); A61K 31/335 (2006.01); A61K 31/397 (2006.01); A61K 31/4427 (2006.01); A61K 31/444 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); A61K 31/335 (2013.01); A61K 31/397 (2013.01); A61K 31/444 (2013.01); A61K 31/4427 (2013.01); A61K 45/06 (2013.01); C07D 313/08 (2013.01); C07D 405/04 (2013.01); C07D 405/10 (2013.01);
Abstract

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.


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