The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 20, 2018

Filed:

Jan. 28, 2016
Applicant:

Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;

Inventors:

Michael Balestra, New Fairfield, CT (US);

Jörg M. Bentzien, White Plains, NY (US);

Jennifer Burke, Newtown, CT (US);

Derek Cogan, Ridgefield, CT (US);

Xin Guo, Danbury, CT (US);

Keith R. Hornberger, Southbury, CT (US);

John Lord, Poughkeepsie, NY (US);

Kenneth M. Meyers, Seymour, CT (US);

Zhaoming Xiong, Ridgefield, CT (US);

Maolin Yu, Brookfield, CT (US);

Zhonghua Zhang, Ridgefield, CT (US);

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61P 13/12 (2006.01); C07D 261/20 (2006.01); C07D 413/04 (2006.01); C07D 413/06 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 261/20 (2013.01); A61P 13/12 (2018.01); C07D 413/04 (2013.01); C07D 413/06 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 498/04 (2013.01);
Abstract

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein X, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.


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